The Impact of Zidovudine (An Antiretroviral Drug) on Some Serum and Erythrocyte Biochemical Parameters in Wistar Albino Rats
ثبت نشده
چکیده
Zidovudine (AZT) is a nucleoside analog, a reverse transcriptase inhibitor (NRTI) and a type of antiretroviral drug used for the treatment of HIV/AIDS. The administration of zidovudine to the wistar albino rats showed an increase in erythrocyte fragility as can be seen from figure 1. There were significant (p<0.05) increases in serum Aspartate aminotranseferase (AST) activity, and GlutathioneStranseferase (GST) activity, The result also showed non-significant (p>0.05) decrease in serum ALP activity, significant (p<0.05) decrease in Fe2+/Fe3+ ratio and NADH methaemoglobin reductase activity. Findings from this study have revealed that zidovudine is hepatotoxic, increases the concentraton of ferric iron in the body thus imparing oxygen transport and also affects the erythrocyte membrane proteins adversely.
منابع مشابه
Examination of Haematotoxicity of Fixed-Dose Highly Active Antiretroviral Drug in Albino Wistar Rats
Highly active antiretroviral therapy (HAART) is considered toxic and has other life-threatening side effects. Our aim was to evaluate the haematotoxic effects of lamivudine, zidovudine, and nevirapine fixed-dose combinations in Albino Wistar rats. Fifty (50) three (3) months old male Albino Wistar rats weighing between 200 and 250 g were randomly assigned to five (5) groups (A, B, C, D, and E)....
متن کاملHepato Protective and Antioxidant Role of Berberis tinctoria lesch Leaves on Paracetamol Induced Hepatic Damage in Rats
The scientific evaluation of medicinal plants used in the preparation of folk remedies has provided modern medicine with effective pharmaceuticals for the treatment of diseases. The methanol extract of Berberis tinctoria Lesch (Berberidaceae) leaves was investigated for its hepatoprotective and antioxidant effects on paracetamol (750 mg/kg) induced acute liver damage in Wistar albino rats. Hepa...
متن کاملEffect of celery,sour apple and carrot in some of serum biochemical parameters of diabetic rats
In order to investigate the effect of celery,sour apple and carrot on some of the biochemical parameters of serum from diabetic rats,25 male adult rats were selected.the rats were divided into 5 groups.a group consisting of 5 rats were chosen as the control group and diabetes mellitus was induced in 20 out of 25 adult male albino rats using intraperitoneal injection of 170mg/kg(body weight) of ...
متن کاملAcute and subchronic toxicity assessment of Melastomastrum capitatum Fern. leaf methanol extract in Wistar albino rats
This study was carried in order to determine short-term (acute) and long-term(subchronic) effects of Melastomastrum capitatum leaf methanol extract in the management and treatment of certain diseases in traditional and complementary medicines by many villages in Mambila Nigeria. Acute and subchronic toxicities were carried out in accordance with the Organization for Economic Cooperation and D...
متن کاملOral toxic exposure of titanium dioxide nanoparticles on serum biochemical changes in adult male Wistar rats
Objective(s): Titanium dioxide (TiO2) nanoparticles (NPs) are widely used in commercial food additives and cosmetics worldwide. Uptake of these nanoparticulate into humans by different routes and may exhibit potential side effects, lags behind the rapid development of nanotechnology. Thus, the present study designed to evaluate the toxic effect of mixed rutile and anatase TiO2 NPs on serum bioc...
متن کامل